Dear User, we plan to release an update of SMAFIRA at March 11th 2026. It will resolve several bugs, that have curtailed the functionality in the past. Please note that your current saved sessions will no longer be available when the new version is released.

SMAFIRA is a free online tool that is intended to support biomedical researchers and animal welfare officers in their efforts to screen the literature database PubMed© for candidate alternative methods to animal experiments. SMAFIRA DOES NOT judge on the suitability of retrieved methods as alternatives. This judgement is reserved to human experts. Anyway, SMAFIRA decreases the time needed to search the literature for candidate alternatives. All you need is a PubMed® identifier (PMID).


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Search for a PubMed® identifier that describes an animal experiment with the research goal of your interest. Insert the PMID in the field. By clicking on the "Search for PUBMED similar articles" button, SMAFIRA will first let you confirm if it is the correct reference article.